2026-01-06 16:29 | John Doe — Example
// SYSTEM STATUS — EXAMPLE DATA (John Doe)
GENOME: John Doe (Example)
SEX: Male (XY)
SNPs: 600,000+
CHIP: 23andMe v5

// ALERTS

! ADH1B slow - alcoholism risk
! FUT2 AA - B12 absorption reduced
! COL5A1 TT - tendon injury risk
! MTHFR AG - 65% activity
! COMT AA - high pain sensitivity
! Migraine genetic risk elevated

// HIGHLIGHTS

+ APOE e2/e3 - Alzheimer's protection
+ Longevity score: 97th percentile
+ VO2max potential: 89%
+ BDNF Val/Val - neuroplasticity
+ TERC CC - longer telomeres
+ IL28B CC - HepC resistance
37/41 core SNPs analyzed
// ANCESTRY EUROPEAN
ORIGIN MARKERS
European 82%
East Asian markers 12%
Other 6%
Y-Haplogroup (Paternal)
R1b-M269
Western Europe, most common in Atlantic regions
PIGMENTATION MARKERS
SNP Gene Genotype Interpretation
rs1426654 SLC24A5 AA European - light skin
rs16891982 SLC45A2 GG European - light skin
rs12913832 HERC2/OCA2 GG Brown/dark eyes
rs17822931 ABCC11 CC Dry earwax (East Asian type)
rs4988235 LCT (MCM6) AG Partial lactose tolerance
// HEALTH RISKS 6 MODERATE
! Important Example demonstration data (John Doe). This is NOT a medical diagnosis. Risk allele presence does not equal disease. Most diseases are polygenic. Consult a geneticist for medical decisions.
CARDIOVASCULAR
SNP Gene Genotype Status Interpretation
rs10757274 9p21 AG MODERATE Moderately elevated CHD risk
rs1333049 9p21 CG MODERATE Moderately elevated risk
rs1801133 MTHFR C677T AG MODERATE Heterozygote - ~65% activity
rs6025 Factor V Leiden CC NORMAL No mutation
DIABETES & METABOLISM
SNP Gene Genotype Status Interpretation
rs7903146 TCF7L2 CC NORMAL Normal risk
rs5219 KCNJ11 TT MODERATE Elevated T2D risk
rs9939609 FTO AT MODERATE +1.5kg weight tendency
rs17782313 MC4R TT NORMAL Normal appetite control
NEUROLOGY
APOE Genotype
e2/e3
Protective - reduced Alzheimer's and cardiovascular risk
SNP Gene Genotype Status Interpretation
rs429358 APOE (e4) TT NORMAL No e4 allele
rs7412 APOE (e2) CT PROTECTIVE e2 carrier - protective
rs6265 BDNF Val66Met CC NORMAL Val/Val - good neuroplasticity
// NUTRITION & METABOLISM 2 ALERTS
!
ADH1B (CC) - Slow metabolizer
Higher alcoholism risk, slower alcohol processing
!
FUT2 (AA) - B12 absorption impaired
Non-secretor, need B12 supplementation
FOOD TOLERANCES
Category SNP Gene Genotype Status
Lactose rs4988235 LCT AG Partial tolerance
Gluten (Celiac) rs2187668 HLA-DQ2.5 CC Low risk
Gluten (Celiac) rs7454108 HLA-DQ8 TT Low risk
CAFFEINE
SNP Gene Genotype Interpretation
rs762551 CYP1A2 AC Intermediate metabolizer
rs5751876 ADORA2A CT Moderate anxiety sensitivity
VITAMINS
Vitamin Gene Genotype Status Action
D GC (VDBP) GT Reduced Monitor 25(OH)D levels
B9 (Folate) MTHFR C677T AG 65% activity Use methylfolate
B12 FUT2 AA Impaired Supplement required
A BCMO1 AT Moderate Prefer retinol over beta-carotene
TASTE
SNP Gene Genotype Trait
rs713598 TAS2R38 GG Supertaster - bitter sensitive
rs72921001 OR6A2 CC Normal cilantro perception
// SPORTS & FITNESS ENDURANCE
Athlete Profile
Endurance
Endurance-dominant with good universal base
VO2max Potential
89%
Excellent genetic potential, responds well to aerobic training
Power potential 50%
Endurance potential 72%
!
COL5A1 (TT) - Increased tendon injury risk
Higher risk for Achilles and patellar tendon injuries. Prioritize warm-up, eccentric exercises, collagen supplementation.
MUSCLE FIBER TYPE
SNP Gene Genotype Interpretation
rs1815739 ACTN3 CT RX - Mixed type, universal abilities
ENDURANCE MARKERS
SNP Gene Genotype Interpretation
rs4253778 PPARA GG High PPARA expression, efficient fat oxidation
rs8192678 PPARGC1A CT Good endurance potential
rs2010963 VEGFA GG Excellent angiogenesis and capillarization
RECOVERY & INJURY
SNP Gene Genotype Interpretation
rs1800629 TNF-a AG Moderate recovery time
rs4880 SOD2 AA Excellent oxidative stress protection
rs12722 COL5A1 TT High tendon injury risk
rs1800012 COL1A1 CC Low ligament rupture risk
PSYCHOLOGY
SNP Gene Genotype Interpretation
rs4680 COMT AA Met/Met - "Worrier", higher anxiety under pressure, but better precision
rs6265 BDNF CC Val/Val - Fast motor learning, excellent motor memory
// PSYCHOLOGY & BEHAVIOR WORRIER
COMT Type
Worrier (Met/Met)
Slow dopamine degradation, higher baseline levels. Better working memory and cognition in calm state. Prone to anxiety and rumination. Worse performance under acute stress.
+
FKBP5 (CC)
More stress resilient
+
BDNF Val/Val
Good neuroplasticity
RISK LEVELS
Parameter Level
Stress sensitivity REDUCED
Addiction risk MODERATE
Depression risk REDUCED
NEUROTRANSMITTER SYSTEMS
SNP Gene Genotype System Interpretation
rs4680 COMT AA Dopamine Met/Met - slow breakdown, higher DA
rs1800497 DRD2/ANKK1 AG Dopamine Moderately reduced D2 receptors
rs6295 HTR1A CG Serotonin Moderate risk
rs53576 OXTR AG Oxytocin Moderate empathy
rs6265 BDNF CC Neuroplasticity Val/Val - normal secretion
// COGNITIVE ABILITIES PROTECTED
COMT Profile
Worrier (Met/Met)
Better working memory and executive functions in calm state. May experience cognitive decline under stress.
APOE Cognitive Risk
e2/e3 - Protected
Slightly reduced risk of cognitive aging
MEMORY
SNP Gene Genotype Interpretation
rs17070145 KIBRA CC Normal episodic memory
rs4680 COMT AA Better working memory at rest
rs6265 BDNF CC Good neuroplasticity
COGNITIVE AGING
SNP Gene Genotype Status
rs429358 APOE (e4) TT No e4 - normal risk
rs7412 APOE (e2) CT e2 carrier - protective
rs9536314 KLOTHO TT KL-VS variant - reduced function
rs2802292 FOXO3 GT Moderately protective
CAFFEINE & COGNITION
SNP Gene Genotype Recommendation
rs762551 CYP1A2 AC Intermediate metabolizer - moderate benefit
rs5751876 ADORA2A CT Moderate anxiety sensitivity - 1-2 cups morning only
// LONGEVITY & AGING 97th PERCENTILE
9.3
Exceptional longevity genetics Top tier - 97th percentile
SCORE BY CATEGORY
Longevity Genes +4.0
APOE +1.5
Telomeres +1.5
Inflammation +0.6
DNA Repair +0.4
Oxidative Stress -0.5
KEY LONGEVITY MARKERS
SNP Gene Genotype Status Effect
rs2802292 FOXO3 GT MODERATE +1.5 years longevity effect
rs9536314 KLOTHO TT BENEFICIAL KL-VS - cognitive protection
rs10936599 TERC CC BENEFICIAL Longer telomeres
rs2736100 TERT AC MODERATE Average telomerase activity
rs4880 SOD2 AA RISK Reduced mitochondrial protection
// SLEEP & CHRONOTYPE EARLY BIRD
Chronotype
Early Bird (Lark)
Strong morning chronotype - naturally wake early, most alert in morning
Sleep Quality Score
6/10
Average genetic sleep quality predisposition
SLEEP MARKERS
Category SNP Gene Genotype Interpretation
Chronotype rs228697 PER3 CC Morning preference, shorter sleep need
Sleep Depth rs73598374 ADA CC Deep sleeper - less sensitive to disturbances
Duration rs1823125 PAX8 AA May need 8-9 hours
Melatonin rs10830963 MTNR1B CC Normal melatonin receptor function
RLS Risk rs3923809 BTBD9 AG Moderate RLS risk
CAFFEINE CUTOFF
2:00 PM
Intermediate caffeine metabolism + moderate sensitivity = avoid caffeine after 2PM
// IMMUNITY HIGH INFLAMMATION
Inflammatory Profile
Pro-inflammatory
3 elevated inflammatory markers - recommend anti-inflammatory diet
+
IL28B (CC)
Good HepC therapy response
+
FUT2 (AA) - Non-secretor
Resistant to norovirus and rotavirus
CYTOKINES
SNP Gene Genotype Status Effect
rs1800629 TNF-alpha AG ELEVATED Higher TNF-alpha production
rs1800795 IL-6 CG ELEVATED Moderately elevated IL-6
rs16944 IL-1beta AG ELEVATED Moderately elevated IL-1beta
CELIAC RISK (HLA-DQ)
SNP Gene Genotype Status
rs2187668 HLA-DQ2.5 CC Low risk (<1%)
rs7454108 HLA-DQ8 TT Low risk
// PAIN SENSITIVITY HIGH SENSITIVITY
Pain Profile (COMT)
Worrier (Met/Met)
High pain sensitivity, low stress resistance, slow dopamine metabolism. May need higher analgesic doses.
Migraine Risk
ELEVATED
Multiple risk markers detected - avoid triggers, keep headache diary
PAIN MARKERS
SNP Gene Genotype Effect
rs4680 COMT AA High pain sensitivity
rs6746030 SCN9A GG Higher pain threshold (protective)
rs1835740 MTDH CC +40% migraine risk
rs11172113 LRP1 TT Elevated migraine risk
NSAID METABOLISM (CYP2C9)
Marker Genotype Status
CYP2C9*2 CT Intermediate metabolizer - dose caution
CYP2C9*3 AA Normal
// DETOXIFICATION 4 ALERTS
!
CYP1B1 (GG)
Increased formation of 4-OH estrogens (more carcinogenic)
!
SOD2 (AA)
Low mitochondrial antioxidant activity - need antioxidant supplements
!
MTRR (GG)
Reduced B12 regeneration - need methyl-B12
!
AS3MT (TT)
Reduced arsenic excretion - avoid exposure
METHYLATION (MTHFR)
MTHFR Status
Mild impairment
C677T heterozygote - ~65% activity. Recommend methylfolate, methyl-B12, avoid folic acid.
SNP Variant Genotype Status
rs1801133 C677T AG Heterozygote - 65%
rs1801131 A1298C GT Normal
CYP450 PHASE I
SNP Gene Genotype Status
rs762551 CYP1A2 AC Intermediate caffeine metabolizer
rs1799853 CYP2C9*2 CT Intermediate metabolizer
rs1056836 CYP1B1 GG High 4-OH estrogen formation
OTHER PATHWAYS
Pathway Status
NAT2 (Acetylation) Fast acetylator
CYP2C19 Normal metabolizer
Alcohol Standard tolerance
// SKIN INFLAMMATION PRONE
!
DDB2 (AA)
Elevated acne risk
!
HLA-C (CT)
Moderate psoriasis risk
+
SOD2 (AA)
High antioxidant protection
+
GSTP1 (AA)
High detox capacity (Ile/Ile)
SKIN MARKERS
Category Gene Genotype Status
Collagen COL1A1 CC Normal structure
Collagen degradation MMP1 DI Moderate
UV sensitivity MC1R CC Normal
Glycation AGER CT Moderate risk
Wound healing TNF-alpha AG Slower healing
// VISION & HEARING 2 HIGH RISK
VISION
AMD (Macular Degeneration) Risk
6.25x
Combined CFH + ARMS2 risk. Regular eye exams recommended, consider AREDS supplements.
Condition SNP Gene Genotype Risk
AMD rs1061170 CFH CT 2.5x
AMD rs10490924 ARMS2 GT 2.5x
Glaucoma rs10483727 SIX6 CC HIGH
Myopia rs634990 RASGRF1 CT MODERATE
Cataracts rs2165241 EPHA2 CT MODERATE
HEARING
Condition SNP Gene Genotype Risk
Meniere's Disease rs4947296 NFKB1 TT HIGH
Noise-Induced Loss rs4880 SOD2 AA Good protection
// PHYSICAL TRAITS
Eye Color Prediction
Blue/Gray
71.4% blue/gray, 19% brown, 9.5% green
Hair Color
Light
Moderate confidence
KEY TRAITS
Trait Gene Genotype Result
Hair thickness EDAR AA Thin hair (European)
Male baldness HDAC9 CC High early baldness risk
Skin SLC24A5 AA Light skin (European)
Earwax ABCC11 CC Dry (East Asian type), less body odor
Bitter taste TAS2R38 GG Supertaster
Cilantro OR6A2 CC Normal - herbal taste
Photic sneeze ZEB2 CC No ACHOO reflex
Freckles MC1R CC Fewer freckles, better tanning
// PHARMACOGENOMICS 1 VARIANT
!
CYP2C9*2 (CT)
Intermediate metabolizer - reduced clearance of warfarin, NSAIDs, some anticonvulsants
DRUG METABOLISM
SNP Gene Genotype Status Affected Drugs
rs4244285 CYP2C19*2 GG Normal Clopidogrel, PPIs, SSRIs
rs1799853 CYP2C9*2 CT Intermediate Warfarin, NSAIDs
rs1057910 CYP2C9*3 AA Normal Warfarin, NSAIDs
rs9923231 VKORC1 CC Normal Warfarin (standard dose)
rs4149056 SLCO1B1 TT Normal Statins (normal risk)
rs1800460 TPMT CC Normal Thiopurines (azathioprine)
// CARRIER STATUS 1 CRITICAL
!! CRITICAL FINDING BRCA1 185delAG (rs80357906) - DD genotype detected. This is a high-risk variant for hereditary breast/ovarian cancer. GENETIC COUNSELING REQUIRED. This result requires confirmation by clinical testing.
CARRIER STATUS SUMMARY
Condition Gene Mutation Genotype Status
Hereditary Cancer BRCA1 185delAG DD HIGH RISK - Counseling needed
Hereditary Cancer BRCA2 6174delT II Normal
Hemochromatosis HFE H63D CG Carrier (usually benign)
Hemochromatosis HFE C282Y GG Normal
A1AT Deficiency SERPINA1 S variant TT SS - ~60% activity
Cystic Fibrosis CFTR G542X TT Normal
PKU PAH R408W GG Normal